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Week 3 NFL Best Bets: Bills, Lions, Seahawks Headline Expert Picks

September 26, 2026 5 min read
Week 3 NFL Best Bets: Bills, Lions, Seahawks Headline Expert Picks

As the 2026 NFL season rolls into Week 3, the action kicked off with a statement: the Atlanta Falcons dismantled the Green Bay Packers 35-14 at Lambeau Field, setting the tone for a weekend ripe with betting opportunities. Reported by the Vulius NFL Analysis Desk, our handicapping team—Matt Jacob, Jeremy Pond, and Matt Russell—has scoured the slate to deliver their best bets. With odds subject to change, here’s where the smart money lies for the rest of Week 3.

Buffalo Bills vs. Los Angeles Chargers: A Spread That Defies Logic

The Buffalo Bills enter Week 3 as 7-point home favorites over the Los Angeles Chargers, and our analysts are split. Matt Jacob pulls no punches: “This point spread makes zero sense.” He points to the Chargers’ offensive struggles—just four touchdowns in two games against defenses that ranked 28th and 25th in scoring last season—and the red-hot Josh Allen, who has accounted for nine total touchdowns (five passing, four rushing) in two weeks. The Bills have scored 77 points, enjoyed a 10-day rest, and are in the midst of a three-game homestand. Meanwhile, the Chargers are traveling cross-country for a 10 a.m. PT kickoff, and their 0-4 spread record in early East Coast games last season looms large. Jacob’s bet: Bills -7.

Matt Russell, however, plays devil’s advocate. He acknowledges the Chargers’ flaws but reminds us that it’s only Week 3—two games is a tiny sample. “The market moved against the Bills’ Week 2 opponent because of rest advantage and Detroit’s thin secondary, yet Buffalo was power-rated as the NFL’s best team before the Rams’ Monday night win,” Russell notes. He also cites a compelling trend: since 2003, teams starting 0-2 are 107-85-5 ATS (55.7%) in Week 3. With the Chargers potentially at their perceived floor and the Bills’ rating inflated, he sees value on Los Angeles. Russell’s bet: Chargers +7.

Jeremy Pond dives into player props, focusing on Bills tight end Dalton Kincaid. The third-year pro has been a revelation, ranking third in the league with 225 receiving yards on 12 catches (14 targets) and a touchdown. “Finally healthy, Kincaid has been on fire,” Pond says. The Chargers’ defense has been torched by Jacoby Brissett and Kirk Cousins for 530 yards and four touchdowns, and now they face Allen, the early MVP favorite. Pond expects Kincaid to continue his hot streak. His bets: Kincaid over 4.5 receptions (+106) and anytime TD (+198).

New York Jets at Detroit Lions: Goff’s Clean Sheet

The Detroit Lions are 6.5-point home favorites against the New York Jets, and Matt Jacob is eyeing a juicy prop: Jared Goff under 0.5 interceptions (-145). The Jets’ defense hasn’t recorded an interception in 19 games—an NFL record—covering 576 pass attempts. Meanwhile, Goff has thrown 77 passes this season without a pick and has been intercepted in just 10 of his last 33 starts. “This wager is a bit juicy, but for good reason,” Jacob explains. With Aaron Glenn’s defense unable to buy a turnover, Goff should keep his clean sheet intact.

Seattle Seahawks at Washington Commanders: Smith-Njigba Shines

The Seattle Seahawks are 7.5-point road favorites against the Washington Commanders, and Jeremy Pond is all over Jaxon Smith-Njigba. With Sam Darnold sidelined, backup Drew Lock has played like an All-Pro, completing 35-of-48 passes for 422 yards and four touchdowns without an interception. Smith-Njigba leads the NFL with 22 receptions for 277 yards and four scores. He’ll likely face Commanders cornerback Mike Sainristil, who has allowed six receptions on eight targets (75%) this season. Pond also likes Seahawks tight end AJ Barner to score anytime, as Washington has surrendered four touchdowns to tight ends in two games. His bets: Smith-Njigba 60+ yards, 7+ receptions, anytime TD (+219) and Barner anytime TD (+320).

Las Vegas Raiders at New Orleans Saints: Juwan Johnson’s Reliability

The New Orleans Saints are 3-point home favorites against the Las Vegas Raiders, and Jeremy Pond is targeting tight end Juwan Johnson over 3.5 receptions (-102). Johnson has been a favorite of quarterback Tyler Shough, hauling in seven catches for 127 yards and a touchdown this season. In 11 games with Shough as the starter, Johnson has 48 receptions for 641 yards and three scores. He’s also had four or more catches in 14 of his last 19 games (82%). “We’re getting an absolute steal here,” Pond says.

Los Angeles Rams at Denver Broncos: Ferguson’s Homecoming

In Sunday Night Football, the Los Angeles Rams are 2.5-point road favorites against the Denver Broncos, and Jeremy Pond highlights tight end Terrance Ferguson. The Littleton, Colorado native returns home and could see an expanded role with Puka Nacua likely out. In Week 2, Ferguson caught six passes for 54 yards and a touchdown. “Back the Heritage High School product to hit pay dirt for the second consecutive game on ‘home’ soil,” Pond urges. His bet: Ferguson anytime TD (+200).

As you finalize your Week 3 wagers, remember that Vulius Sports provides unparalleled analysis and exclusive merchandise to elevate your game day experience. Whether you’re backing the Bills’ high-octane offense or trusting the trends, our team has you covered. Stay tuned for more insights and gear up with Vulius—where fandom meets expertise.

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