As the NFL season charges into Week 4 on this October 2, 2026, the injury landscape continues to reshape matchups and fantasy lineups alike. According to insights gathered by Vulius Sports, the latest updates reveal a mix of returns and absences that will significantly impact the weekend's action. From star receivers to franchise quarterbacks, here's the comprehensive breakdown you need to know before kickoff.
Puka Nacua Set to Return for Rams
Los Angeles Rams wide receiver Puka Nacua will make his much-anticipated return against the Philadelphia Eagles after missing the past two games with a hip and groin issue. Head coach Sean McVay noted that Nacua "looked sharp" in practice, though he will likely be on a snap count. "It's exciting," Nacua told reporters. "That's my safe space out there, and to be out there with the guys, I think that's been the most important thing, feeling that camaraderie and then also the ability to put my foot in the ground." His presence provides a major boost for Matthew Stafford and the Rams' offense.
Justin Jefferson Ruled Out with Ankle Sprain
In a significant blow to the Minnesota Vikings, four-time All-Pro wide receiver Justin Jefferson will miss Sunday's game against the Miami Dolphins due to a left ankle sprain suffered in Week 3. This marks his first absence since the 2023 season. Despite playing limited snaps in Week 3, Jefferson still leads the team with 179 receiving yards on 13 receptions, including two touchdowns. His absence will put added pressure on quarterback J.J. McCarthy and the rest of the receiving corps.
Jayden Daniels Out; Caleb Williams Sidelined Again
Washington Commanders quarterback Jayden Daniels has been ruled out for the London matchup against the Indianapolis Colts with an elbow injury. Daniels practiced in a limited capacity this week, wearing a brace on his left arm. While surgery may be needed in the offseason, the brace will protect him for the remainder of the season. Meanwhile, Chicago Bears quarterback Caleb Williams will sit another week due to a hamstring injury. Head coach Ben Johnson said, "We'll find out on Sunday" regarding the starting quarterback, with Case Keenum and Tyson Bagent as the candidates to play.
Eagles Without DeVonta Smith; Jets Lose Breece Hall
The Philadelphia Eagles will be without wideout DeVonta Smith on Sunday night against the Rams. Smith, who leads the team with 19 receptions and 235 receiving yards, suffered a hamstring injury on Monday night and did not practice all week. With A.J. Brown also out, Jalen Hurts will rely on Dontayvion Wicks, Makai Lemon, and returning Zach Ertz. For the New York Jets, running back Breece Hall has been ruled out with a quad injury, paving the way for Braelon Allen to start. "Nothing really changes for me in terms of preparation or my mindset," Allen said. "I've always prepared to be in that position."
Other Notable Injuries to Monitor
San Francisco 49ers wide receiver Mike Evans is dealing with a rib injury and remained out of practice on Thursday, though head coach Kyle Shanahan said the veteran "will make every attempt" to play against the Denver Broncos. The injury report is extensive, with key players like Trey Hendrickson (finger), Zay Flowers (hamstring), and Baker Mayfield (thumb) also ruled out. For a full team-by-team breakdown, visit Vulius.com for the latest updates and fantasy implications.
"It's exciting. That's my safe space out there, and to be out there with the guys... the ability to put my foot in the ground." – Puka Nacua
Stay tuned to Vulius for continued coverage and in-depth analysis as Week 4 unfolds. For official NFL merchandise and gear, explore our collection to support your team through every injury update.
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